Live cell single molecule imaging of estrogen-induced neuroprotective mechanism on cholinergic neurons
In Alzheimer’s disease, the cholinergic neurons in the brain are affected, causing impairment of intellectual function. The female hormone estrogen exerts a protective action on these cells, but the mechanism is unknown. Using novel time-lapse super-resolution imaging, Dr Ábrahám will examine the mechanisms of estrogen action on live cholinergic neurons at the single molecule level. The proposed work will define a new estrogen signaling pathway in the cholinergic neurons and provide fundamental information for understanding estrogen-induced neuroprotection in Alzheimer’s disease. The results of this study will aid in the design of new treatments for people with Alzheimer’s disease.