The following grants were approved prior to December 2012.
$2,204Ms Treena Blythe Department of Biochemistry, Massey University 1996 - June
Research Society on Alcoholism Washington DC June 1996 Symposium on enzymology, South Dakota July 1996
$4,700Dr David de Vries University of Otago 1995 - December
Domoic acid (shellfish toxin) is a potent human neurotoxin with a unique pharmacological profile. This study will serve as a pilot experiment to evaluate the biochemical and neurological approach to understanding domoic acid neurotoxicity and the development of new ways to limit domoic acid medicated neurological damage.
$4,900Dr Steve Kerr Department of Pharmacology and Toxicology, University of Otago 1995 - December
Domoic acid is produced by a number of marine phytoplankton species and has been observed in shellfish following seasonal phytoplankton blooms. Consumption of affected shellfish can produce severe neurological symptoms. Laboratory based studies of the effect of domoic acid on hippocampal neurophysiology will be carried out.
$76,000Dr Neil Domigan Christchurch School of Medicine 1995 - June
Motor Neurone disease: Amyotrophic lateral sclerosis (motor neurone disease) is an adult-onset disorder that results in loss of muscle control. Mutations in the gene for the enzyme superoxide dismutase can be responsible for some of the inherited cases of the disorder. Recently this research group has found a New Zealand family with motor neurone disease and a mutation in the enzymes. This study will contribute to the understanding of how motor neurones are damaged and help in the management of individuals with MND.
$28,000Dr Gregory Funk Department of Physiology, University of Auckland 1995 - June
This research will lead to an understanding of the brain mechanisms associated with nervous system disorders of breathing that involve the upper airway. One common example of such disorders is cot death or sudden infant death syndrome (SIDS). A full understanding of these disorders requires knowledge of the factors that control the neurons which regulate the respiratory systems muscle activity. The study will examine the mechanisms by which the brain controls the activity of the relevant motor neurons during development.